Analysis of Oseltamivir in Tamiflu Capsules Using Micellar Electrokinetic Chromatography

Analysis of oseltamivir in Tamiflu capsules using micellar electrokinetic chromatography.

A simple and rapid micellar electrokinetic chromatography (MEKC) method was developed for the analysis of an antiviral drug, oseltamivir, and its hydrolyzed product in Tamiflu capsules. Background electrolytes consisted of boric acid 10 mM, pH 10, and sodium dodecyl sulphate (SDS) 40 mM. The limit of detection (LOD) and limit of quantification (LOQ) of oseltamivir were 1.7 and 8.0 microg/ml, re...

Micellar electrokinetic chromatography.

Modeling The Capacity Factor of Analytes in Micellar Electrokinetic Chromatography Using Computational Descriptors

       A multiple linear regression model is proposed to calculate capacity factor of  analytes using structural features computed using HyperChem software. The  chemical descriptors of analytes were computed using HyperChem software and  regressed against the experimental capacity factors of analytes collected from the  literature. The absolute average percentage deviation (AARD) and individua...

Principles of micellar electrokinetic capillary chromatography applied in pharmaceutical analysis.

Since its introduction capillary electrophoresis has shown great potential in areas where electrophoretic techniques have rarely been used before, including here the analysis of pharmaceutical substances. The large majority of pharmaceutical substances are neutral from electrophoretic point of view, consequently separations by the classic capillary zone electrophoresis; where separation is base...

Retention indices in micellar electrokinetic chromatography

The use o f retent ion indices in mice l la r electrokinet ic ch roma tog raphy ( M E K C ) is eva lua ted both f rom a theoretical and a practical point o f view. F undamen t a l equa t ions for the de te rmina t ion o f retent ion indices in M E K C are descr ibed, showing that re tent ion indices are independen t o f the surfac tant concentra t ion. Possibi l i t ies as well as l imita t ion...